An article Novel Aminopyrazole Tagged Hydrazones as Anti-Tubercular Agents: Synthesis and Molecular Docking Studies WOS:000627232100004 published article about MYCOBACTERIUM-TUBERCULOSIS; BIOLOGICAL EVALUATION; INHIBITORS; DERIVATIVES; INHA; ANTIBACTERIAL; IDENTIFICATION; REDUCTASE; DESIGN; OPTIMIZATION in [Padmini, Thatavarthi; Kamal, Bigala Raj] Mewar Univ, Chittaurgarh, Rajasthan, India; [Bhikshapathi, Darna] Teegala Ram Reddy Coll Pharm, Hyderabad 500097, Telangana, India; [Suresh, Kandagatla] Vijaya Coll Pharm, Hyderabad 501511, Telangana, India; [Kulkarni, Ravindra] Bharati Vidyapeeths Poona Coll Pharm, Pune 411038, Maharashtra, India in 2021, Cited 44. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Quality Control of 4-Methoxybenzaldehyde
Background: Pyrazole derivatives have been reported to possess numerous pharmacological activities viz., anti-inflammatory, antipsychotic, etc. Our group has disclosed that pyrazole benzamides display potent antibacterial and anti-tubercular activities. Objective: Synthesis of new pyrazole acetamides which possess hydrazone group to be evaluated for antitubercular activity. Methods: The key intermediate 5-aminopyrazole was synthesized with the known procedure, which is then converted into chloroacetamide. This compound than resulted in hydrazine derivative and finally converted into aromatic hydrazones. All the compounds were screened for antitubercular activity. Result: All the synthesized compounds have been characterized by their spectral data obtained and subjected to anti-tubercular activity. Among all the twenty tested compounds, three compounds, 5a5, 5b5 and 5b7 have demonstrated MIC value of 3.12 mu g/mL against MTB H37Rv. Docking studies revealed important hydrogen bonding interactions with InhA. Conclusion: Three compounds 5a5, 5b5 and 5b7 were found to be most potent among the series of compounds. Docking studies of compounds explained the presence of hydrogen bonding and pp stacking interactions with InhA. Further synthesis of more such derivatives with optimized groups would produce compounds with more potent anti-tubercular activity.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles