COA of Formula: C7H8O2. Recently I am researching about SPHINGOSINE 1-PHOSPHATE; FINGOLIMOD FTY720; ORAL FINGOLIMOD; BMS-986104; PREDICTION; ARTHRITIS; S1P1, Saw an article supported by the . Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Xiao, ZL; Yang, MG; Dhar, TGM; Xiao, HY; Gilmore, JL; Marcoux, D; McIntyre, KW; Taylor, TL; Shi, H; Levesque, PC; Marino, AM; Cornelius, G; Mathur, A; Shen, DR; Cvijic, ME; Lehman-McKeeman, LD; Sun, HD; Xie, JH; Carter, PH; Dyckman, AJ. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol
Efforts aimed at increasing the in vivo potency and reducing the elimination half-life of 1 and 2 led to the identification of aryl ether and thioether-derived bicyclic S1P(1) differentiated modulators 3-6. The effects of analogs 3-6 on lymphocyte reduction in the rat (desired pharmacology) along with pulmonary- and cardiovascular-related effects (undesired pharmacology) are described. Optimization of the overall properties in the aryl ether series yielded 3d, and the predicted margin of safety against the cardiovascular effects of 3d would be large enough for human studies. Importantly, compared to 1 and 2, compound 3d had a better profile in both potency (ED50 < 0.05 mg/kg) and predicted human half-life (t(1/2) similar to 5 days). COA of Formula: C7H8O2. Welcome to talk about 150-19-6, If you have any questions, you can contact Xiao, ZL; Yang, MG; Dhar, TGM; Xiao, HY; Gilmore, JL; Marcoux, D; McIntyre, KW; Taylor, TL; Shi, H; Levesque, PC; Marino, AM; Cornelius, G; Mathur, A; Shen, DR; Cvijic, ME; Lehman-McKeeman, LD; Sun, HD; Xie, JH; Carter, PH; Dyckman, AJ or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles