Recently I am researching about OXIDE-RELEASING DERIVATIVES; NITRIC-OXIDE; BETA-CARBOLINES; CELL-CYCLE; ANTICANCER ACTIVITY; NATURAL-PRODUCTS; APOPTOSIS; INHIBITORS; KINASE; COMBINATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773604]; Career Development Support Plan for Young and Middleaged Teachers in Shenyang Pharmaceutical University. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Hu, X; Gao, X; Gao, G; Wang, YB; Cao, H; Li, DH; Hua, HM. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. COA of Formula: C8H8O2
The cytotoxicity properties of the beta-carboline alkaloids have been broadly investigated. However, the potential application of beta-carbolines was hindered due to the moderate activity in cancer. In the present study, thirty beta-carboline-(phenylsulfonyl)furoxan hybrids (11a-j, 12a-j and 13a-j) were designed and synthesized through esterification and amidation reaction strategy, and their inhibitory activities against the human breast cancer cell lines MCF-7 and MDA-MB-231 were evaluated by CCK-8 assay. Biological evaluation presented that the most promising amide derivative 13h, substituted with p-methoxyphenyl group at position 1, generated high concentration of NO and evidently depressed the MCF-7 (IC50 = 0.89 mu M) and MDA-MB-231 (IC50 = 0.62 mu M) cells proliferation. Particularly, the wound healing and transwell assays demonstrated that 13h significantly inhibited the migration and invasion of MDA-MB-231cells. Furthermore, the preliminary mechanisms studies indicated that 13h induced G2/M phase arrest and apoptosis possibly causing by ROS accumulation and ROS-mediated DNA damage. Based on these considerations, 13h may be a promising antimetastatic agent for breast cancer, which is noteworthy for further exploration.
COA of Formula: C8H8O2. Welcome to talk about 123-11-5, If you have any questions, you can contact Hu, X; Gao, X; Gao, G; Wang, YB; Cao, H; Li, DH; Hua, HM or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles