The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane(SMILESS: C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1,cas:132098-59-0) is researched.Recommanded Product: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole. The article 《A study on chiral organocalcium complexes: attempts in enantioselective catalytic hydrosilylation and intramolecular hydroamination of alkenes》 in relation to this compound, is published in Zeitschrift fuer Naturforschung, B: Chemical Sciences. Let’s take a look at the latest research on this compound (cas:132098-59-0).
The chiral β-diketimine ligand [(S)-Ph(Me)CH-N:C(Me)]CH2 was prepared by condensation of acetylacetone with the com. available chiral building block (S)-Ph(Me)CH-NH2. Reaction of bis(o-Me2N-α-Me3Si-benzyl)calcium with this β-diketimine led to double deprotonation. Reaction of bis(o-Me2N-α-Me3Si-benzyl)calcium with the com. available chiral bis-oxazoline (S)-Ph-BOX gave diastereopure [(S)-Ph-BOX](o-Me2N-α-Me3Si-benzyl)calcium which in solution slowly decomposed with formation of o-Me2N-α-Me3Si-toluene. The corresponding amide complex [(S)-Ph-BOX]CaN(SiMe3)2·(THF)2 is stable and the crystal structure has been determined In solution, this heteroleptic amide is in Schlenk equilibrium with the homoleptic species [(S)-Ph-BOX]2Ca and Ca[N(SiMe3)2]2·(THF)2. This Schlenk equilibrium can be steered to the heteroleptic side. Use of the enantiopure calcium amide catalyst for the hydrosilylation of styrene with PhSiH3 or in the intramol. hydroamination of aminoalkenes gave good product yields, but only small ee-values were observed (5-10%). From stoichiometric reactions of the catalyst with the substrates it is concluded that the “”true”” catalytically active species is mainly present as a homoleptic calcium complex, which explains the poor enantioselectivities.
Although many compounds look similar to this compound(132098-59-0)Name: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane, numerous studies have shown that this compound(SMILES:C1(CC2=N[C@@H](C3=CC=CC=C3)CO2)=N[C@@H](C4=CC=CC=C4)CO1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles