Catalytic enantioselective synthesis of macrodiolides and their application in chiral recognition was written by Xiao, Wanlong;Mo, Yuhao;Guo, Jing;Su, Zhishan;Dong, Shunxi;Feng, Xiaoming. And the article was included in Chemical Science in 2021.Category: indole-building-block This article mentions the following:
New types of C2-sym. chiral macrodiolides are readily obtained via chiral N,N’-dioxide-scandium(III) complex-promoted asym. tandem Friedel-Crafts alkylation/intermol. macrolactonization of ortho-quinone methides with C3-substituted indoles. This protocol provides an array of enantioenriched macrodiolides with 16, 18 or 20-membered rings in moderate to good yields with high diastereoselectivities and excellent enantioselectivities through adjusting the length of the tether at the C3 position of indoles. D. functional theory calculations indicate that the formation of macrocycles is more favorable than that of 9-membered-ring lactones in terms of kinetics and thermodn. The potential utility of these intriguing chiral macrodiolide mols. is demonstrated in the enantiomeric recognition of aminols and chem. recognition of metal ions. In the experiment, the researchers used many compounds, for example, 4-Methyl-1H-indole (cas: 16096-32-5Category: indole-building-block).
4-Methyl-1H-indole (cas: 16096-32-5) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles