CuI-catalyzed intramolecular cyclization of 3-(2-aminophenyl)-2-bromoacrylate: synthesis of 2-carboxyindoles was written by Xiao, Xiong;Chen, Tian-Qi;Ren, Jiangmeng;Chen, Wei-Dong;Zeng, Bu-Bing. And the article was included in Tetrahedron Letters in 2014.HPLC of Formula: 210345-56-5 This article mentions the following:
A new approach was described for the synthesis of substituted 2-indolecarboxylates using 3-(2-aminophenyl)-2-bromoacrylates through a CuI-catalyzed intramol. coupling. The reactions were mild, rapid, and with good to excellent yields. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5HPLC of Formula: 210345-56-5).
Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.HPLC of Formula: 210345-56-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles