Xing, Fei; Zhang, Qilong; Gao, Lingfeng; Zheng, Gengxiu published the artcile< Fabrication of a fluorescent probe for in-situ and ratiometric visualization of autophagy>, Recommanded Product: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one, the main research area is fluorescent probe autophagy; Autophagy; Fluorescent probe; Ratiometric; pH sensitive.
In situ and real-time visualization of autophagy process is of vital importance for fundamental researches in biol. However, fluorescent probes for autophagy were rarely reported, which greatly hindered the study on autophagy. A fluorescent probe was rationally designed and fabricated for the ratiometric visualization of autophagy. The probe targeted non-lysosome organelles in healthy cells, and gave blue emission. During autophagy, the organelles together with the probe were delivered into acid lysosomes, and gave red fluorescence. In this way, the autophagy process could be monitored in ratiometric manner. The starvation induced autophagy was successfully visualized by the probe, and the inhibition effect of chloroquine to autophagy was also observed The authors expect that the probe can serve as powerful tool for the study of autophagy and relative areas.
Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Autophagy. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Recommanded Product: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles