Xiong, W.-N. published the artcileSynthesis of Novel Analogues of Marine Indole Alkaloids: Mono(indolyl)-4-trifluoromethylpyridines and Bis(indolyl)-4-trifluoromethylpyridines as Potential Anticancer Agents, Related Products of indole-building-block, the publication is Bioorganic & Medicinal Chemistry (2001), 9(7), 1773-1780, database is CAplus and MEDLINE.
Mono(indolyl)-4-trifluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines were synthesized using Suzuki cross-coupling reaction between 2-chloro-4-trifluoromethylpyridine 9,2,6-dichloro-4-trifluoromethylpyridine or 2,6-dichloro-3-cyano-4-trifluoromethylpyridine 23 and N-tosyl-3-indolylboronic acid. They were evaluated for cytotoxic activity against P388 and A-549 cells with IC50 values. 4-Trifluoromethyl-2,6-bis[3′-(N-tosyl-6′-methoxylindolyl)]pyridine (I) was identified as the most potent in this series. The synthesis and anticancer activities of the mono(indolyl)-4-trfluoromethylpyridines and bis(indolyl)-4-trifluoromethylpyridines are reported.
Bioorganic & Medicinal Chemistry published new progress about 149108-61-2. 149108-61-2 belongs to indole-building-block, auxiliary class Indole,Boronic acid and ester,Sulfamide,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (1-tosyl-1H-Indol-3-yl)boronic acid, and the molecular formula is C7H10BNO4S, Related Products of indole-building-block.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles