Synthesis and assessment of bisindoles as a new class of antibacterial agents was written by Yan, Xue;Tang, Ying-De;He, Fei;Yu, Shu-Juan;Liu, Xigong;Bao, Jie;Zhang, Hua. And the article was included in Monatshefte fuer Chemie in 2020.Application of 4769-96-4 This article mentions the following:
Antimicrobial screening of an inhouse library containing both natural products and synthetic compounds identified a bisindole mol. as a selective antibacterial hit. Further evaluation and structural modification afforded a series of dimeric indole derivatives, most of which showed moderate to good antibacterial activity against two Gram-pos. strains Staphylococcus aureus and Bacillus subtilis. Chiral HPLC was employed to sep. these racemates and the bioactive differences between the enantiomeric pairs were also assessed and discussed. Three dihalogenaged analogs also showed mild growth inhibition against a drug-resistant S. aureus strain. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Application of 4769-96-4).
6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 4769-96-4
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles