On November 1, 2014, Yang, Jun; Zhou, Shanshan; Ji, Liyan; Zhang, Chao; Yu, Siwang; Li, Zhongjun; Meng, Xiangbao published an article.Name: 6-Chloro-2,3-dihydro-1H-indole The title of the article was Synthesis and structure-activity relationship of 4-azaheterocycle benzenesulfonamide derivatives as new microtubule-targeting agents. And the article contained the following:
A series of 1-sulfonyl indolines was synthesized and evaluated for antiproliferative activity. The most potent compounds I (R = H or MeO) showed significant cytotoxicity (IC50 in the range of 0.055-0.105 and 0.039-0.112 μM, resp.) against four human cancer cell lines HCT116, PC3, HepG2 and SK-OV-3. The structure-activity relationship of this series of sulfonamides, including the influence of azaheterocycle rings, substituent at the different positions of indolines, and the cyclopropane moiety, was described. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Name: 6-Chloro-2,3-dihydro-1H-indole
The Article related to indoline azaheterocycle benzenesulfonamide preparation microtubule targeting agent antitumor, benzenesulfonamides, indoline, microtubule-targeting agents, synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Name: 6-Chloro-2,3-dihydro-1H-indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles