Yang, Song published the artcileRhodium-catalyzed asymmetric hydroamination and hydroindolation of keto-vinylidenecyclopropanes, Safety of 4-Chloroindoline, the main research area is indolinyl tetrahydropyridinol preparation regioselective enantioselective; indoline keto vinylidenecyclopropane hydroamination rhodium catalyst; indolyl tetrahydropyridinol preparation regioselective enantioselective; indole keto vinylidenecyclopropane hydroindolation rhodium catalyst; amino tetrahydropyridinol preparation regioselective enantioselective; secondary amine keto vinylidenecyclopropane hydroamination rhodium catalyst.
A highly regio- and enantioselective hydroamination and hydroindolation of keto-vinylidenecyclopropanes via cationic Rh(I) catalysis was reported in this context. The combination of indolines, various secondary amines and indoles with keto-vinylidenecyclopropanes afforded the corresponding hydrofunctionalization products, e.g., I, II and III resp. in good to excellent yields with outstanding ee values under mild conditions. A new TMM-Rh model complex was proposed, providing an atom economical Rh-π-allyl precursor at the same time. Moreover, the resulting products could easily be transformed into more complex polyheterocycles upon further synthetic manipulation.
Chemical Science published new progress about Bromides Role: RCT (Reactant), RACT (Reactant or Reagent) (α-keto). 41910-64-9 belongs to class indole-building-block, name is 4-Chloroindoline, and the molecular formula is C8H8ClN, Safety of 4-Chloroindoline.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles