On January 13, 2011, Yao, Chun-Hsu; Song, Jen-Shin; Chen, Chiung-Tong; Yeh, Teng-Kuang; Hung, Ming-Shiu; Chang, Chih-Chun; Liu, Yu-Wei; Yuan, Mao-Chia; Hsieh, Chieh-Jui; Huang, Chung-Yu; Wang, Min-Hsien; Chiu, Ching-Hui; Hsieh, Tsung-Chih; Wu, Szu-Huei; Hsiao, Wen-Chi; Chu, Kuang-Feng; Tsai, Chi-Hui; Chao, Yu-Sheng; Lee, Jinq-Chyi published an article.Reference of 6-Chloro-2,3-dihydro-1H-indole The title of the article was Discovery of Novel N-β-D-Xylosyl-indole Derivatives as Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes. And the article contained the following:
A novel series of N-linked β-D-xylosides were synthesized and evaluated for inhibitory activity against sodium-dependent glucose co-transporter 2 (SGLT2) in a cell-based assay. Of these, the β-D-xylopyranosyl-1H-indole I (R = 4-chlorocyclopropylbenzyl) was the most potent inhibitor, with an EC50 value similar to that of the natural SGLT2 inhibitor phlorizin. Further studies in Sprague-Dawley (SD) rats indicated that I significantly increased urine glucose excretion in a dose-dependent manner with oral administration. The antihyperglycemic effect of I was also observed in streptozotocin (STZ) induced diabetic SD rats. These results described here are a good starting point for further investigations into N-glycoside SGLT2 inhibitors. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Reference of 6-Chloro-2,3-dihydro-1H-indole
The Article related to aryl c glycoside preparation antidiabetic, human xyloside indole sglt2 inhibitor hyperglycemia diabetes antidiabetic preparation, Carbohydrates: Glycosides and other aspects.Reference of 6-Chloro-2,3-dihydro-1H-indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles