Ye, Ya-Xi; Guan, Jing; Chen, Xin-Yue; Yu, Ya-Wen; Xu, Zhu-Min; Zeng, Shang-Ming-Zhu; Wang, Zhong-Chang; Wang, Bao-Zhong; Jiao, Qing-Cai; Zhu, Hai-Liang published the artcile< A new fluorescently labeled bisphosphonate for theranostics in tumor bone metastasis>, Application of C30H36N4O2, the main research area is bisphosphonate hydroxyapatite bone metastasis fluorescence; Bisphosphonate; Bone metastasis; Fluorescence imaging; Hydroxyapatite; pH-sensitivity.
Bone metastasis of malignant solid tumors has become one of the most serious complications, especially in breast cancer, which was particularly challenging for early detection and treatment in clin. practice. In this work, we reported a new fluorescently labeled bisphosphonate for bone metastasis detection of breast cancer. The designed probes were based on Rhodamine B and bisphosphonate as recognition group, which can specifically target hydroxyapatite (HA) existed in bone tissue. After the osteoclasts were adsorbed on the bone surface, the surrounding microenvironment was acidified, causing the HA to locally dissolve. The probe bound to the HA was then released, and realized the fluorescence turn on under acidic conditions. In vitro experiments showed that G0 was more excellent than G2 owing to shorter connecting arm. Subsequently, we proved that G0 could combine with HA rapidly and exhibit excellent response in solid state. More importantly, we established a model of bone metastasis with MDA-MB-231 cells which was similar to the clin. cases and evaluated the theranostics value of G0 prospectively, which provide the potential application prospect in clin.
Talanta published new progress about Antitumor agents. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Application of C30H36N4O2.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles