Yenireddy, Veera Reddy et al. published their research in Chemical Data Collections in 2022 | CAS: 90271-86-6

5-Bromo-3-cyanoindole (cas: 90271-86-6) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Electric Literature of C9H5BrN2

Synthesis, characterization, biological evaluation and molecular docking of novel amide derivatives of indole-1,2,4-oxadiazole clubbed thiazoles was written by Yenireddy, Veera Reddy;Vejendla, Anuradha. And the article was included in Chemical Data Collections in 2022.Electric Literature of C9H5BrN2 This article mentions the following:

In the present study, a series of some novel amide derivatives of indole-1,2,4-oxadiazole clubbed thiazoles I (Ar = 4-MeC6H4, 4-ClC6H4, 4-BrC6H4, etc.) were designed and prepared Antiproliferative activity of these compounds against four human cancer cell lines such as SiHa (cervix), A549 (lung), MCF-7 (breast) and Colo-205 (colon) evaluated by using MTT assay and compared with therapeutic agent etoposide. Among them, compounds I (Ar = 3,4,5-triMeOC6H2, 3,5-diMeOC6H3, 4-MeOC6H4, 2-thiazolyl, 4-pyridyl) demonstrated very potent activity. Mol. modeling studies were performed on the binding site of Human Protein tyrosine kinase 6 (PTK6) to correlate the outcome of in vitro cytotoxic assays and therefore rationalize the binding interactions. In silico ADME and toxicity experiment were shown that all synthesized compounds have good oral bioavailability and free from toxicity. In the experiment, the researchers used many compounds, for example, 5-Bromo-3-cyanoindole (cas: 90271-86-6Electric Literature of C9H5BrN2).

5-Bromo-3-cyanoindole (cas: 90271-86-6) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Electric Literature of C9H5BrN2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles