In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Dipyrrinato-Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation, published in 2021-04-11, which mentions a compound: 1008-89-5, mainly applied to dipyrrinato iridium complex preparation antimicrobial photodynamic inactivation therapy; crystal structure dipyrrinato iridium complex antimicrobial photodynamic inactivation therapy; mol structure dipyrrinato iridium complex; dipyrromethane oxidation chloroanil reagent; (dipyrrinato)iridium(III) complexes; antimicrobial photodynamic inactivation; dipyrrins; glycosylation; photodynamic therapy, Application of 1008-89-5.
The generation of bio-targetable photosensitizers is of utmost importance to the emerging field of photodynamic therapy and antimicrobial (photo-)therapy. A synthetic strategy is presented in which chelating dipyrrin moieties were used to enhance the known photoactivity of Ir(III) metal complexes. Formed complexes can thus be functionalized in a facile manner with a range of targeting groups at their chem. active reaction sites. Dipyrrins with N- and O-substituents afforded (dipy)iridium(III) complexes via complexation with the resp. Cp*-Ir(III) and ppy-Ir(III) precursors (dipy = dipyrrinato, Cp* = pentamethyl-η5-cyclopentadienyl, ppy = 2-phenylpyridyl). Similarly, electron-deficient [Ir(III)(dipy)(ppy)2] complexes could be used for post-functionalization, forming alkenyl, alkynyl and glyco-appended Ir(III) complexes. The phototoxic activity of these complexes was assessed in cellular and bacterial assays with and without light; the [Ir(III)(Cl)(Cp*)(dipy)] complexes and the glyco-substituted Ir(III) complexes showing particular promise as photomedicine candidates. Representative crystal structures of the complexes are also presented.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles