Yu, Shun published the artcileStability of human serum albumin structure upon toxin uptake explored by small angle neutron scattering, COA of Formula: C8H6KNO4S, the publication is Polymer (2018), 175-183, database is CAplus.
The possible denaturation or tertiary structural changes of human serum albumin (HSA) upon adsorption of uremic toxin was investigated using small-angle neutron scattering (SANS). Calorimetric data in previous studies provided proof of binding between HSA and 2 classes of uremic toxins: (1) small-mol.-weight (SMW) toxins and (2) middle-mol.-weight (MMW) toxins. Polyacrylic acid, a representative polyelectrolyte of neg. net charge, was used as a model MMW toxin and 2 mols. [phenylacetic acid (PhAA) and indoxyl sulfate (IDS)] represented the SMW toxins. The present study found no proof of destabilization of the protein structure upon toxin uptake. Analyzing the structure factor of scattering intensities from high concentrated protein samples complexed with PhAA and IDS showed that interaction between native and complexed HSA was also not altered. However, a small effect of the net charge of HSA was found in the case of urea-modified proteins.
Polymer published new progress about 2642-37-7. 2642-37-7 belongs to indole-building-block, auxiliary class Indole,Salt,Sulfonate,Inhibitor,Inhibitor, name is Potassium 1H-indol-3-yl sulfate, and the molecular formula is C11H15BFNO4, COA of Formula: C8H6KNO4S.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles