Intermolecular C-H Amidation of (Hetero)arenes to Produce Amides through Rhodium-Catalyzed Carbonylation of Nitrene Intermediates was written by Yuan, Si-Wen;Han, Hui;Li, Yan-Lin;Wu, Xueli;Bao, Xiaoguang;Gu, Zheng-Yang;Xia, Ji-Bao. And the article was included in Angewandte Chemie, International Edition in 2019.Recommanded Product: 7-Fluoroindole This article mentions the following:
Amide bond formation is one of the most important reactions in organic chem. because of the widespread presence of amides in pharmaceuticals and biol. active compounds Existing methods for amides synthesis are reaching their inherent limits. Described herein is a novel rhodium-catalyzed three-component reaction to synthesize amides from organic azides, carbon monoxide, and (hetero)arenes via nitrene-intermediates and direct C-H functionalization. Notably, the reaction proceeds in an intermol. fashion with N2 as the only byproduct, and neither directing groups nor additives are required. The computational and mechanistic studies show that the amides are formed via a key Rh-nitrene intermediate. Thus, e.g., 1-methylindole + CO + TsN3 → 1-methyl-N-tosylindole-3-carboxamide (92%, 88% isolated) in presence of [Rh(cod)Cl]2 in MeCN. In the experiment, the researchers used many compounds, for example, 7-Fluoroindole (cas: 387-44-0Recommanded Product: 7-Fluoroindole).
7-Fluoroindole (cas: 387-44-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Recommanded Product: 7-Fluoroindole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles