Synthesis of some 1-acetylindoline-5-sulfonyl amino acid derivatives and studies of their antimicrobial activities was written by Zaher, M. R.;Kora, F. A.;Hussein, M. E.;El-Sayed, R. A.;El-Naggar, A. M.. And the article was included in Farmaco, Edizione Scientifica in 1986.Reference of 52206-05-0 This article mentions the following:
Title amino acid derivatives I (R = amino acid residue or corresponding Me ester or hydrazide, dipeptide Me ester residue) were prepared from 1-acetylindoline-5-sulfonyl chloride and amino acids or esters and optional hydrazinolysis or peptide coupling. Most I (27 compounds) showed antimicrobial activity against a variety of microorganisms. In the experiment, the researchers used many compounds, for example, 1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0Reference of 52206-05-0).
1-Acetylindoline-5-sulfonyl chloride (cas: 52206-05-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Reference of 52206-05-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles