In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Zhang, Jitan; Wu, Manyi; Fan, Jian; Xu, Qiaoqiao; Xie, Meihua. Electric Literature of C8H6FN. The article was titled 《Selective C-H acylation of indoles with α-oxocarboxylic acids at the C4 position by palladium catalysis》. The information in the text is summarized as follows:
The first Pd-catalyzed direct C-H acylation of indoles at the C4 position with α-oxocarboxylic acids using a ketone directing group was described. This reaction exhibited high regioselectivity with the tolerance of a wide scope of functional groups to afford diverse acylated indoles I [R = Me, Ph, Bn, Ts; R1 = H, Me, Ph; R2 = H, Me, Et, t-Bu, Ph; R3 = Ph, 4-MeC6H4, 2-thienyl, etc.; R4 = H, 5-F, 6-Br, etc.] in moderate to good yields. The control experiments evidenced the generation of acyl radicals via K2S2O8 promoted decarboxylation of α-oxocarboxylic acids and the involvement of a PdII/PdIV catalytic cycle. Importantly, the synthetically useful selectivity observed might be applied to prepare indole derivatives with anti-tumor activity as tubulin inhibitors. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0Electric Literature of C8H6FN)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Electric Literature of C8H6FN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles