First discovery of pimprinine derivatives and analogs as novel potential herbicidal, insecticidal and nematicidal agents was written by Zhang, Ming-Zhi;Mulholland, Nick;Seville, Anne;Hough, Gemma;Smith, Nicholas;Dong, Hong-Qiang;Zhang, Wei-Hua;Gu, Yu-Cheng. And the article was included in Tetrahedron in 2021.SDS of cas: 827-01-0 This article mentions the following:
Pimprinine and streptochlorin are indole natural products produced by many species of organisms, and they are reported to possess a wide range of biol. activities, such as anticancer, antiviral, antifungal activity and so on. In this study, three series of pimprinine derivatives or analogs were efficiently synthesized under the optimized methods. Biol. assays conducted at Syngenta firstly indicated the pimprinine derivatives or analogs possessed potential herbicidal and insecticidal activity, and this is highlighted by several compounds that possessed significant biol. activity as well as broad spectrum. Meanwhile, compounds with benzothiophene-oxazole core showed effective nematicidal activity in primary screening. Compounds 5-(benzofuran-3-yl)oxazole and 5-(benzodioxol-5-yl)oxazole were identified as the most promising lead structures for further study. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0SDS of cas: 827-01-0).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.SDS of cas: 827-01-0
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Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles