Zhang, Ming-Zhi; Chen, Qiong; Xie, Cai-Hong; Mulholland, Nick; Turner, Sarah; Irwin, Dianne; Gu, Yu-Cheng; Yang, Guang-Fu; Clough, John published the artcile< Synthesis and antifungal activity of novel streptochlorin analogues>, Application In Synthesis of 4771-48-6, the main research area is streptochlorin analog preparation antifungal; Antifungal activity; Natural product; Streptochlorin; Structure–activity relationships; Synthesis.
Streptochlorin, first isolated as a new antibiotic in 1988 from the lipophilic extracts of the mycelium of a Streptomyces sp., is an indole natural product with a variety of biol. activities. Based on the methods developed for the synthesis of pimprinine in our laboratory, we have synthesized a series of indole-modified streptochlorin analogs and measured their activities against seven phytopathogenic fungi. Some of the analogs displayed good activity in the primary assays, and seven compounds were identified as the most promising candidates for further study. Structural optimization is still ongoing with the aim of discovering synthetic analogs with improved antifungal activity.
European Journal of Medicinal Chemistry published new progress about Fungicides. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Application In Synthesis of 4771-48-6.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles