Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B was written by Zhang, Nanjing;Turpoff, Anthony;Zhang, Xiaoyan;Huang, Song;Liu, Yalei;Almstead, Neil;Njoroge, F. George;Gu, Zhengxian;Graci, Jason;Jung, Stephen P.;Pichardo, John;Colacino, Joseph;Lahser, Fred;Ingravallo, Paul;Weetall, Marla;Nomeir, Amin;Karp, Gary M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Recommanded Product: 5-Fluoro-6-methyl-1H-indole The following contents are mentioned in the article:
A novel series of 2-(4-sulfonamidophenyl)-indole 3-carboxamides was identified and optimized for activity against the HCV genotype 1b replicon resulting in compounds with potent and selective activity. Further evaluation of this series demonstrated potent activity across HCV genotypes 1a, 2a and 3a. Compound I had reduced activity against HCV genotype 1b replicons containing single mutations in the NS4B coding sequence (F98C and V105M) indicating that NS4B is the target. This novel series of 2-(4-sulfonamidophenyl)-indole 3-carboxamides serves as a promising starting point for a pan-genotype HCV discovery program. This study involved multiple reactions and reactants, such as 5-Fluoro-6-methyl-1H-indole (cas: 1000343-16-7Recommanded Product: 5-Fluoro-6-methyl-1H-indole).
5-Fluoro-6-methyl-1H-indole (cas: 1000343-16-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 5-Fluoro-6-methyl-1H-indole
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles