Sulfuric acid catalyzed rapid nucleophilic substitution of propargyl alcohols was written by Zhang, Shunji;Liu, Huili. And the article was included in Youji Huaxue in 2020.Recommanded Product: 6-Nitro-1H-indole This article mentions the following:
Sulfuric acid efficiently catalyzes the direct substitution of the hydroxyl group of propargylic alcs. R1C(OH)CCR2 (R1 = 3,4-dimethoxyphenyl, 4-(benzyloxy)phenyl, 3-(trifluoromethyl)phenyl, etc.; R2 = pentyl, Ph, 4-methoxyphenyl) with a variety of C- and O-based nucleophiles such as isopropanol, phenol, furan, etc. to aid C-C and C-O bond formation. The reactions can be performed in an undried solvent under air atm. to obtain the desired products R1C(R3)CCR2 (R3 = OMe, furan-2-yl, 4-hydroxyphenyl, etc.) in good yields. In most cases, the reaction proceeds to completion in 1 min at room temperature In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Recommanded Product: 6-Nitro-1H-indole).
6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 6-Nitro-1H-indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles