Zhang, Wenzheng; Xu, Guangyang; Qiu, Lin; Sun, Jiangtao published an article in 2018, the title of the article was Gold-catalyzed C5-alkylation of indolines and sequential oxidative aromatization: access to C5-functionalized indoles.Recommanded Product: 52537-00-5 And the article contains the following content:
A novel protocol for the synthesis of C5-alkylated indole derivatives I (R = C(O)OCH3, naphthalen-2-yl, thiophen-2-yl, etc.; R1 = CH3, CH2C6H5, pyrimidin-2-yl, etc.; R2 = H, 3-CH3, 2-CH3; R3 = 4-CN, 6-Cl, 7-CH3O, etc.) via a gold-catalyzed reaction of indolines II with diazo compounds RC(=N2)C(O)OCH3 and subsequent oxidative aromatization has been developed. C-H bond functionalization selectively occurs at the C5-position of indolines III without a directing group. The exptl. operation is simple and the whole process can be manipulated in one-pot. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 52537-00-5
The Article related to alkyl indoline preparation regioselective, diazo compound indoline alkylation gold catalyst, indole alkyl preparation regioselective, indoline diazo compound alkylation gold catalyst oxidative aromatization and other aspects.Recommanded Product: 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles