Zhang, Xiaoxiang; Zhang, Yingying; Gu, Xiaoting; Zhang, Zhuan; Wei, Wanxing; Liang, Taoyuan published the artcile< Synthesis of 3-halogenated 2,3'-biindoles by a copper-mediated 2,3-difunctionalization of indoles>, Formula: C10H9NO2, the main research area is halo biindole green regioselective preparation; indole difunctionalization catalyst copper.
A copper-mediated 2,3-difunctionalization of indoles to afford 3-halogenated 2,3′-biindoles I [R1 = 5-Me, 4-Cl, 5-Cl, etc.; R2 = Me, Et, Ph, etc.; X = Cl, Br] was described herein. The protocol uses readily available feedstocks and a naturally abundant copper catalyst system, which allowed the regioselective formation of C-C and C-X (X = Cl and Br) bonds in one single operation. Here the copper metal salt served not only as a catalyst but also as a reactant to provide the source of halogen. This operationally simple procedure avoided the utilization of environmentally unfriendly reagents and displays good functional group compatibility. Noteworthily, the introduction of halogen into mols. would offered great potential for further chem. transformations.
Organic & Biomolecular Chemistry published new progress about C-C bond formation. 93247-78-0 belongs to class indole-building-block, and the molecular formula is C10H9NO2, Formula: C10H9NO2.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles