Zhang, Yan; Hu, Zhe-Yao; Li, Xin-Chang; Guo, Xun-Xiang published the artcile< Copper-Catalyzed Decarboxylative N-Arylation of Indole-2-Carboxylic Acids>, Name: 5-Fluoroindole-2-carboxylic acid, the main research area is aryl indole preparation; indole carboxylic acid aryl halide copper catalyst decarboxylative arylation.
A novel decarboxylative N-arylation of indole-2-carboxylic acids with aryl halides was developed. The reaction proceeded efficiently in the presence of Cu2O as the catalyst to give the corresponding N-aryl indoles I [R1 = 4-Me, 5-F, 6-MeO, etc.; R2 = Ph, 3-FC6H4, 4-ClC6H4, etc.] in high yields. This synthetic method showed good functional group tolerance and offered an alternative route to construct N-aryl indoles.
Synthesis published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 399-76-8 belongs to class indole-building-block, and the molecular formula is C9H6FNO2, Name: 5-Fluoroindole-2-carboxylic acid.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles