Organocatalytic Asymmetric Arylative Dearomatization of 2,3-Disubstituted Indoles Enabled by Tandem Reactions was written by Zhang, Yu-Chen;Zhao, Jia-Jia;Jiang, Fei;Sun, Si-Bing;Shi, Feng. And the article was included in Angewandte Chemie, International Edition in 2014.Recommanded Product: 5-Bromo-2,3-dimethyl-1H-indole This article mentions the following:
The organocatalytic asym. arylative dearomatization of indoles was achieved through two tandem approaches involving 2,3-disubstituted indoles and quinone imine ketals. One approach utilized the enantioselective cascade 1,4 addition/alc. elimination reaction, the other employed the one-pot tandem arylative dearomatization/transfer hydrogenation sequence. In both cases, enantiomerically pure indole derivatives I [R1 = H, 4-Me, 5-Me, etc; R2 = Me, Et; R3 = Me, Et; R = Me, Et, Pr-i, Bu; PG = Boc, Cbz] and II [R1 = H, 4-Me, 5-Me, etc; R2 = Me, Et; R3 = Me, Et; R = Me, Et, Pr-i, Bu; PG = Boc, Cbz] that bear an all-carbon quaternary stereogenic center were generated in high yields and excellent stereoselectivities (all d.r.>95:5, up to 99 % ee). In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Recommanded Product: 5-Bromo-2,3-dimethyl-1H-indole).
5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 5-Bromo-2,3-dimethyl-1H-indole
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles