On November 4, 2002, Zhao, He; He, Xiaoshu; Thurkauf, Andrew; Hoffman, Diane; Kieltyka, Andrzej; Brodbeck, Robbin; Primus, Renee; Wasley, Jan W. F. published an article.Formula: C9H9NO2 The title of the article was Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 2: Asymmetric synthesis and biological evaluation. And the article contained the following:
A series of chiral benzylpiperazinyl-1-(2,3-dihydroindol-1-yl)ethanone derivatives were prepared and examined for their affinity at dopamine D2 and D4 receptors. Three compounds having D2/D4 affinity ratios approximating that found for the atypical neuroleptic clozapine were further evaluated in behavioral tests of antipsychotic efficacy and motor side effects. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Formula: C9H9NO2
The Article related to dopamine receptor antagonist antipsychotic indoline piperazine derivative, Pharmacology: Structure-Activity and other aspects.Formula: C9H9NO2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles