Zhao, Yu et al. published their research in European Journal of Medicinal Chemistry in 2021 | CAS: 4382-54-1

5-Methoxyindole-2-carboxylic acid (cas: 4382-54-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: 5-Methoxyindole-2-carboxylic acid

Design, synthesis, and structure activity relationship analysis of new betulinic acid derivatives as potent HIV inhibitors was written by Zhao, Yu;Chen, Chin-Ho;Morris-Natschke, Susan L.;Lee, Kuo-Hsiung. And the article was included in European Journal of Medicinal Chemistry in 2021.Name: 5-Methoxyindole-2-carboxylic acid This article mentions the following:

Prior modification of betulinic acid (1), a natural product lead with promising anti-HIV activity, produced 3-O-(3′,3′-dimethylsuccinyl)betulinic acid (bevirimat, 3, III), the first-in-class HIV maturation inhibitor. After 3-resistant variants were found during Phase I and IIa clin. trials, further modification of 3 produced 4 (IV) with improved activity against wild-type and 3-resistant HIV-1. In continued efforts to optimize 1, 63 final products have now been designed, synthesized, and evaluated for anti-HIV-1 replication activity against HIV-1NL4-3 infected MT-4 cell lines. Five known and 21 new derivatives were as or more potent than 3 (EC50 0.065μM), while eight new derivatives were as or more potent than 4 (EC50 0.019μM). These derivatives feature expanded structural diversity and chem. space that may improve the antiviral activity and address the growing resistance crisis. Structure-Activity Relationship (SAR) correlations were thoroughly analyzed, and a 3D Quant. SAR model with high predictability was constructed to facilitate further rational design and development of new potent derivatives In the experiment, the researchers used many compounds, for example, 5-Methoxyindole-2-carboxylic acid (cas: 4382-54-1Name: 5-Methoxyindole-2-carboxylic acid).

5-Methoxyindole-2-carboxylic acid (cas: 4382-54-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: 5-Methoxyindole-2-carboxylic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles