Zheng, Rimei; Xu, Aimin; Huang, Jiawu; Zhang, Zhijing; Yin, Xinru; Zhang, Tianyuan; Hu, Wenhao; Qian, Yu published an article in , the title of the article was A Rh(II)-catalyzed highly stereoselective [3 + 2] annulation of vinyl diazoacetates with indole-2-carbaldehyde for the synthesis of indolyl dihydrofurans.Product Details of 883526-76-9 And the article contains the following content:
A highly stereoselective Rh2(Oct)4catalyzed [3 + 2] cycloaddition of vinyl diazoacetates 2,6-(Me)2C6H3OC(O)C(=N2)CH=CHAr (Ar = Ph, 2-naphthyl, 2-methylphenyl, etc.) with indolyl aldehydes I (R = Me, Bn; R1 = 5-Cl, 3-Me, 5-Me, etc.) has been developed. This protocol provides an efficient access to both cis and trans indolyl dihydrofurans (4R,5R/4R,5S)-II with high yields and diastereoselectivities under mild conditions without or with Lewis acid as additive, resp. Moreover, these generated functionalized dihydrofurans exhibit potent antiproliferation activity in three different cancer cell lines. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).Product Details of 883526-76-9
The Article related to indolyl dihydrofuran preparation diastereoselective chemoselective, vinyl diazoacetate indole carbaldehyde cycloaddition rhodium catalyst, carbonyl ylide, indolyl dihydrofurans, vinyl metal carbene and other aspects.Product Details of 883526-76-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles