On March 2, 2016, Zhong, Wenhe; Jin, Chuanfei; Zhang, Yingjun; Zhang, Ji published a patent.Reference of 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Preparation of indoline derivatives for treating or preventing diseases related with 5-HT6 receptor. And the patent contained the following:
The invention relates to indoline derivatives (e.g., I), their stereoisomers, tautomers, nitrogen oxides, solvates, metabolites and pharmaceutically acceptable salts, and prodrugs thereof, processes for preparing them, pharmaceutical preparations comprising them, and their use for treating or preventing diseases related with 5-HT6 receptor. For instance, the invention compound I was prepared and gave a 5-HT6 Ki value of 57 nM. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Reference of 6-Chloro-2,3-dihydro-1H-indole
The Article related to indoline preparation hydroxytryptamine gastrointestinal antiobesity cns, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Reference of 6-Chloro-2,3-dihydro-1H-indole
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles