Zhou, Su; Liu, Qianqian; Bao, Ming; Huang, Jie; Wang, Junjian; Hu, Wenhao; Xu, Xinfang published an article in 2021. The article was titled 《Gold(I)-catalyzed redox transformation of o-nitroalkynes with indoles for the synthesis of 2,3′-biindole derivatives》, and you may find the article in Organic Chemistry Frontiers.SDS of cas: 399-52-0 The information in the text is summarized as follows:
An efficient and practical methods for the syntheses of 2-indolyl indolone N-oxides I [R = H, Me, CH2CH=CH2; R1 = 4-F, 5-Cl, 6-Me, etc.; R2 = H, 6-Me, 7-F, etc.; R3 = H, Me] and 1’H,3H-[2,3′-biindol]-3-ones II [R4 = H, Ph, Bn, 4-ClPhCH2; R5 = H, 6-Me, 5-F, 7-F ] via gold(I)-catalyzed cascade reaction of o-nitroalkynes with indoles were reported. The generated product could be readily converted into the 2-indolylbenzoxazinone, which emitted strong blue fluorescence. Also some of the compounds I and II evaluated for antitumor activity for small cell lung cancer and the results showed that compounds I [R = H; R1 = 6-Me; R2 = H; R3 = H] and II [R4 = H; R5 = 6-Me] exhibited high anticancer potency against SCLC cells. In addition to this study using 5-Fluoro-1H-indole, there are many other studies that have used 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0) was used in this study.
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 399-52-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles