Ru-catalyzed oxidation and C-C bond formation of indoles for the synthesis of 2-indolyl indolin-3-ones under mild reaction conditions was written by Zhou, Xiao-Yu;Chen, Xia. And the article was included in Canadian Journal of Chemistry in 2020.Synthetic Route of C10H11NO This article mentions the following:
Herein, a ruthenium catalyzed oxidation and C-C bond formation reaction of 2-alkyl or 2-aryl substituted indoles using tert-Bu hydroperoxide (TBHP) as oxidant is described. Coupled with cascade transformation, it provided a mild catalytic oxidation system for the synthesis of 2-indolylindolin-3-ones I (R = Me, Ph, 4-FC6H4, etc.; R1 = H, Me, Et; R2 = 5-Me, 5-OMe, 5-Cl) . The reaction could readily occur using RuCl3路3H2O as catalyst, and the target product was obtained with medium to high yield. In the experiment, the researchers used many compounds, for example, 5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0Synthetic Route of C10H11NO).
5-Methoxy-2-methyl-1H-indole (cas: 1076-74-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Synthetic Route of C10H11NO
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles