Catalyst-free system for sulfenylation of free (N–H) indoles with 2,2′-dithiosalicylic acid under alkaline conditions was written by Zhou, Xiaofei;Li, Xinhua. And the article was included in RSC Advances in 2014.Synthetic Route of C8H6FN This article mentions the following:
A catalyst-free system for the sulfenylation of free (N–H) indoles using 2,2′-dithiosalicylic acid under alk. conditions was reported. The system provided a green, convenient and efficient synthesis of sulfenylindoles I [R = 4-Me, 7-F, 5-Br, etc.], with good yields and high selectivity. The synthesis was performed in a green solvent (isopropanol and H2O) under atm. and catalyst-free conditions. The procedure was suitable for use with N-unprotected indoles. An electrophilic coupling mechanism was proposed. In the experiment, the researchers used many compounds, for example, 7-Fluoroindole (cas: 387-44-0Synthetic Route of C8H6FN).
7-Fluoroindole (cas: 387-44-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Synthetic Route of C8H6FN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles