Zhou, Zijun; Li, Yanjun; Gong, Lei; Meggers, Eric published the artcile< Enantioselective 2-Alkylation of 3-Substituted Indoles with Dual Chiral Lewis Acid/Hydrogen-Bond-Mediated Catalyst>, Application In Synthesis of 4771-48-6, the main research area is enantioselective alkylation indole unsaturated acylimidazole chiral cyclometalated iridium complex; bifunctional chiral Lewis acid hydrogen bond mediated alkylation catalyst; pyrroloindole preparation.
A chiral-at-metal bis-cyclometalated iridium complex combines electrophile activation via metal coordination with nucleophile activation through hydrogen bond formation [e.g., indole I + acylimidazole II → III (89% conversion, 98% ee (S)) in presence of Δ-Ir complex IV.BARF]. This new bifunctional chiral Lewis acid/hydrogen-bond-mediated catalyst permits the challenging enantioselective 2-alkylation of 3-substituted indoles with α,β-unsaturated 2-acylimidazoles in up to 99% yield and with up to 98% enantiomeric excess at a catalyst loading of 2 mol %. As an application, the straightforward synthesis of a chiral pyrrolo[1,2-a]indole is demonstrated.
Organic Letters published new progress about Alkylation catalysts, stereoselective. 4771-48-6 belongs to class indole-building-block, and the molecular formula is C10H9NO, Application In Synthesis of 4771-48-6.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles