Natural reversal of pulmonary vascular remodeling and right ventricular remodeling in SU5416/hypoxia-treated Sprague-Dawley rats was written by Zungu-Edmondson, Makhosazane;Shults, Nataliia V.;Melnyk, Oleksiy;Suzuki, Yuichiro J.. And the article was included in PLoS One in 2017.Safety of (Z)-3-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one This article mentions the following:
Pulmonary arterial hypertension (PAH) is a lethal disease and improved therapeutic strategies are needed. Increased pulmonary arterial pressure, due to vasoconstriction and vascular remodeling, causes right ventricle (RV) failure and death in patients. The treatment of Sprague-Dawley rats with SU5416 injection and exposure to chronic hypoxia for three weeks followed by maintenance in normoxia promote progressive and severe PAH with pathol. features that resemble human PAH. At 5-17 wk after the SU5416 injection, PAH is developed with pulmonary vascular remodeling as well as RV hypertrophy and fibrosis. The present study investigated subsequent events that occur in these PAH animals. At 35 wk after the SU5416 injection, rats still maintained high RV pressure, but pulmonary vascular remodeling was significantly reduced. Metabolomics anal. revealed that lungs of normal rats and rats from the 35-wk time point had different metabolomics profiles. Despite the maintenance of high RV pressure, fibrosis was resolved at 35-wk. Masson’s trichrome stain and Western blotting monitoring collagen 1 determined 12% fibrosis in the RV at 17-wk, and this was decreased to 5% at 35-wk. The level of myofibroblasts was elevated at 17-wk and normalized at 35-wk. These results suggest that biol. systems possess natural ways to resolve pulmonary and RV remodeling. The resolution of RV fibrosis appears to involve the reduction of myofibroblast- dependent collagen synthesis. Understanding these endogenous mechanisms should help improve therapeutic strategies to treat PAH and RV failure. In the experiment, the researchers used many compounds, for example, (Z)-3-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one (cas: 194413-58-6Safety of (Z)-3-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one).
(Z)-3-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one (cas: 194413-58-6) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Safety of (Z)-3-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)indolin-2-one
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles